Item Type | Name |
Concept
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Antigens, Neoplasm
|
Concept
|
Antibodies, Neoplasm
|
Concept
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Breast Neoplasms
|
Concept
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Bone Neoplasms
|
Concept
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Colonic Neoplasms
|
Concept
|
Uterine Cervical Neoplasms
|
Concept
|
Digestive System Neoplasms
|
Concept
|
DNA, Neoplasm
|
Concept
|
Facial Neoplasms
|
Concept
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Mammary Neoplasms, Experimental
|
Concept
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Neoplasms, Radiation-Induced
|
Concept
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Neoplasm Seeding
|
Concept
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Neoplasm Transplantation
|
Concept
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Mammary Tumor Virus, Mouse
|
Concept
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Pancreatic Neoplasms
|
Concept
|
Neoplasm Staging
|
Concept
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Ovarian Neoplasms
|
Concept
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Lung Neoplasms
|
Concept
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Prostatic Neoplasms
|
Concept
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Rectal Neoplasms
|
Concept
|
RNA, Neoplasm
|
Concept
|
Vaginal Neoplasms
|
Concept
|
Biomarkers, Tumor
|
Concept
|
Tumor Necrosis Factor-alpha
|
Concept
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Transplantation Immunology
|
Concept
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Antigens, Tumor-Associated, Carbohydrate
|
Concept
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Drug Resistance, Neoplasm
|
Concept
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Tumor Cells, Cultured
|
Concept
|
Lymphocytes, Tumor-Infiltrating
|
Concept
|
Mouth Neoplasms
|
Concept
|
Neoplasm Metastasis
|
Concept
|
Neoplasms, Experimental
|
Concept
|
Receptors, Tumor Necrosis Factor
|
Concept
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Receptors, Tumor Necrosis Factor, Member 14
|
Concept
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Peritoneal Neoplasms
|
Concept
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Tumor Burden
|
Concept
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Tumor Escape
|
Concept
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Tumor Necrosis Factor Ligand Superfamily Member 14
|
Concept
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Stomach Neoplasms
|
Concept
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Tumor Necrosis Factors
|
Concept
|
Skin Neoplasms
|
Concept
|
Colorectal Neoplasms
|
Concept
|
Tumor Microenvironment
|
Concept
|
Cell Line, Tumor
|
Concept
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Brain Neoplasms
|
Concept
|
Neoplasm Proteins
|
Concept
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Neoplasms
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Academic Article
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A tumor escape variant that has lost one major histocompatibility complex class I restriction element induces specific CD8+ T cells to an antigen that no longer serves as a target.
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Academic Article
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Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.
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Academic Article
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DNA sequence analysis of T-cell receptor genes reveals an oligoclonal T-cell response to a tumor with multiple target antigens.
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Academic Article
|
Prevention of runting and cachexia by a chimeric TNF receptor-Fc protein.
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Academic Article
|
Footprinting of individual tumors and their variants by constitutive cytokine expression patterns.
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Academic Article
|
Genetically engineered vaccines. Comparison of active versus passive immunotherapy against solid tumors.
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Academic Article
|
Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.
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Academic Article
|
Immunodominance deters the response to other tumor antigens thereby favoring escape: prevention by vaccination with tumor variants selected with cloned cytolytic T cells in vitro.
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Academic Article
|
The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68.
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Academic Article
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Radiation can inhibit tumor growth indirectly while depleting circulating leukocytes.
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Academic Article
|
Unique tumor antigens redefined as mutant tumor-specific antigens.
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Academic Article
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Tumor cells induce cytolytic T cells to a single immunodominant mutant peptide.
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Academic Article
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Immunological enhancement of primary tumor development and its prevention.
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Academic Article
|
Tracking the common ancestry of antigenically distinct cancer variants.
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Academic Article
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Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens.
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Academic Article
|
Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.
|
Academic Article
|
Tumor antigens.
|
Academic Article
|
Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein.
|
Academic Article
|
Establishment of an HLA-A*0201 human papillomavirus type 16 tumor model to determine the efficacy of vaccination strategies in HLA-A*0201 transgenic mice.
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Academic Article
|
Role of TGF-beta in immune-evasion of cancer.
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Academic Article
|
MHC class I restricted T cells and immune surveillance against transplanted ultraviolet light-induced tumors.
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Academic Article
|
C-kit+ FcR+ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum.
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Academic Article
|
Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells.
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Academic Article
|
Priming of naive T cells inside tumors leads to eradication of established tumors.
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Academic Article
|
Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation.
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Academic Article
|
Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.
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Academic Article
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Genetic changes occurring in established tumors rapidly stimulate new antibody responses.
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Academic Article
|
A new murine tumor model for studying HLA-A2-restricted anti-tumor immunity.
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Academic Article
|
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.
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Academic Article
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Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors.
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Academic Article
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The role of stroma in immune recognition and destruction of well-established solid tumors.
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Academic Article
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Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18.
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Academic Article
|
Cancer immunotherapy and preclinical studies: why we are not wasting our time with animal experiments.
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Academic Article
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Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice.
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Academic Article
|
Inflammation as a tumor promoter in cancer induction.
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Academic Article
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Specificity in cancer immunotherapy.
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Academic Article
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Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
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Academic Article
|
Ribosomal versus non-ribosomal cellular antigens: factors determining efficiency of indirect presentation to CD4+ T cells.
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Academic Article
|
A mutant chaperone converts a wild-type protein into a tumor-specific antigen.
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Academic Article
|
Antibody recognition of a unique tumor-specific glycopeptide antigen.
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Academic Article
|
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.
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Academic Article
|
Densely granulated murine NK cells eradicate large solid tumors.
|
Academic Article
|
Cancer. Quo vadis, specificity?
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Academic Article
|
Highly immunogenic regressor tumor cells can prevent development of postsurgical tumor immunity.
|
Academic Article
|
Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes.
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Academic Article
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IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers.
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Academic Article
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Rapid destruction of the tumor microenvironment by CTLs recognizing cancer-specific antigens cross-presented by stromal cells.
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Academic Article
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Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity.
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Academic Article
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Antigenic cancer cells that escape immune destruction are stimulated by host cells.
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Academic Article
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Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells.
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Academic Article
|
Targeting stroma to treat cancers.
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Academic Article
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CD40 ligation restores cytolytic T lymphocyte response and eliminates fibrosarcoma in the peritoneum of mice lacking CD4+ T cells.
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Academic Article
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Spleen cells from young but not old immunized mice eradicate large established cancers.
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Academic Article
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Relationship of tumour necrosis factor and endotoxin to macrophage cytotoxicity, haemorrhagic necrosis and lethal shock.
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Academic Article
|
A unique tumor antigen produced by a single amino acid substitution.
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Academic Article
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Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.
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Academic Article
|
Cancer. Awakening immunity.
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Academic Article
|
Unique tumor-specific antigens.
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Academic Article
|
Identification of a gene encoding a tumor-specific antigen that causes tumor rejection.
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Academic Article
|
Tumor antigens defined by cloned immunological probes are highly polymorphic and are not detected on autologous normal cells.
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Academic Article
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Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction.
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Academic Article
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[CA 12-5 in cancer of the digestive tract. A comparison with CA 19-9 and CEA in cancer of the pancreas and colon].
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Academic Article
|
Antiproliferative effects exerted by recombinant human tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human pancreatic tumor cell lines.
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Academic Article
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CD4+ and B lymphocytes in transplantation immunity. II. Augmented rejection of tumor allografts by mice lacking B cells.
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Academic Article
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Tumor necrosis factor/cachectin. Induction of hemorrhagic necrosis in normal tissue requires the fifth component of complement (C5).
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Academic Article
|
Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.
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Academic Article
|
Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases.
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Academic Article
|
CD4-positive and B lymphocytes in transplantation immunity. I. Promotion of tumor allograft rejection through elimination of CD4-positive lymphocytes.
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Academic Article
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Equilibrium between host and cancer caused by effector T cells killing tumor stroma.
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Academic Article
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Animals bearing malignant grafts reject normal grafts that express through gene transfer the same antigen.
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Academic Article
|
Tumor-specific immune responses.
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Academic Article
|
Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family.
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Academic Article
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[Immunocytologic detection of disseminated tumor cells in the peritoneal cavity and bone marrow in patients with pancreatic carcinoma].
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Academic Article
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Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells.
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Academic Article
|
Tumor-specific antigens and tumor-specific mutant proteins in mouse and man.
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Academic Article
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Inhibition of tumor growth by elimination of granulocytes.
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Academic Article
|
CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma.
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Academic Article
|
Immunodominance and tumor escape.
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Academic Article
|
Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.
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Academic Article
|
Bystander elimination of antigen loss variants in established tumors.
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Academic Article
|
Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.
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Academic Article
|
Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase.
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Academic Article
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In vivo administration of anti-CD3 prevents malignant progressor tumor growth.
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Academic Article
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Tumors with reduced expression of a cytotoxic T lymphocyte recognized antigen lack immunogenicity but retain sensitivity to lysis by cytotoxic T lymphocytes.
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Academic Article
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Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients.
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Academic Article
|
Isolated tumor cells are frequently detectable in the peritoneal cavity of gastric and colorectal cancer patients and serve as a new prognostic marker.
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Academic Article
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IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner.
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Academic Article
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Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
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Academic Article
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MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
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Academic Article
|
Design and characterization of a protein superagonist of IL-15 fused with IL-15Ra and a high-affinity T cell receptor.
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Academic Article
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[Clinical aspects and therapy of Merkel cell tumor--report of 4 personal cases and review of the literature].
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Academic Article
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Innate and adaptive immune cells in the tumor microenvironment.
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Academic Article
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Editorial overview: tumour immunology.
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Academic Article
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Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression.
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Academic Article
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Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors--letter.
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Academic Article
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Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer.
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Academic Article
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Targeting cancer-specific mutations by T cell receptor gene therapy.
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Academic Article
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Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.
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Academic Article
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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.
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Academic Article
|
Tumor-associated fibroblasts predominantly come from local and not circulating precursors.
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Academic Article
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Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium.
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Academic Article
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Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer.
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Academic Article
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A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth.
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Academic Article
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Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication.
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Academic Article
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Tumour ischaemia by interferon-? resembles physiological blood vessel regression.
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Academic Article
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Active immunization against cancer cells: impediments and advances.
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Academic Article
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Fibroblasts: Dangerous travel companions.
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Academic Article
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A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody.
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Academic Article
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Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen-Specific T Cells.
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Academic Article
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Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.
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Academic Article
|
Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors.
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Academic Article
|
Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.
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Academic Article
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LyP-1-Modified Oncolytic Adenoviruses Targeting Transforming Growth Factor ß Inhibit Tumor Growth and Metastases and Augment Immune Checkpoint Inhibitor Therapy in Breast Cancer Mouse Models.
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Academic Article
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Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides.
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Academic Article
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Criteria to make animal studies more relevant to treating human cancer.
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Grant
|
CD8+ T cells and Immunological Tumor Regression
|
Grant
|
TRANSFORMING GENES AND IMMUNOLOGICAL TUMOR REGRESSION
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Grant
|
Manipulation of Tumor Specific Immunity
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Grant
|
Interdisciplinary Training Program in Immunology
|
Grant
|
IMMUNITY AND CANCER
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Grant
|
MANIPULATION OF TUMOR-SPECIFIC IMMUNITY
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Grant
|
Immunology of Unique Tumor Specific Antigens
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Academic Article
|
Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model.
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Academic Article
|
The Safety and Efficacy of Systemic Delivery of a New Liver-de-targeted TGFß Signaling Inhibiting Adenovirus in an Immunocompetent Triple Negative Mouse Mammary Tumor Model.
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Academic Article
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One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication.
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Academic Article
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The safety and efficacy of systemic delivery of a new liver-de-targeted TGFß signaling inhibiting adenovirus in an immunocompetent triple negative mouse mammary tumor model.
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